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KMID : 0363620160370020001
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Journal of Korean Oriental Medicine
2016 Volume.37 No. 2 p.1 ~ p.11
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Effect of Jaeumkanghwatang (JEKHT), a Polyherbal Formula on the Pharmacokinetics Profiles of Tamoxifen in Male SD Rats (1) - Single Oral Combination Treatment of Tamoxifen 50 mg/kg with JEKHT 100 mg/kg within 5 min -
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Kwak Min-Ah
Park Soo-Jin
Park Sung-Hwan
Lee Young-Joon
Ku Sae-Kwang
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Abstract
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Objectives: The objective of this study was to elucidate the effect of Jaeumkanghwatang (JEKHT) on the plasma
concentration and pharmacokinetics of tamoxifen in combination therapy as a process of the comprehensive and integrative medicine against breast cancer.
Methods: After 50 mg/kg of tamoxifen treatment, JEKHT 100 mg/kg was orally administered within 5 min. The plasma were collected at 30 min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of JEKHT treatment, and plasma concentrations of tamoxifen were analyzed using LC-MS/MS methods. PK parameters of tamoxifen (Tmax, Cmax, AUC, t1/2 and MRTinf) were analysis as compared with tamoxifen single administered rats.
Results: JEKHT did not influenced on the plasma concentrations and pharmacokinetics of tamoxifen after single oral
co-administration, within 5min except for some negligible effects on plasma concentration. The Tmax, Cmax, AUC, t1/2
and MRTinf of tamoxifen in co-administered rats were quite similar to those of tamoxifen single treated rats.
Conclusions: Based on the results of the present study, JEKHT did not influenced on the oral bioavailability of tamoxifen, when they were single co-administered within 5min. However, more detail pharmacokinetic studies should be tested to conclude the possibilities that can be used as comprehensive and integrative therapy with JEKHT and tamoxifen for breast cancers, when they were co-administered, like the effects on the pretreatment of JEKHT and after repeat co-administrations.
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KEYWORD
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Jaeumkanghwatang, Pharmacokinetics, Drug-drug interactions, Rat, Tamoxifen, NolvadexTM
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